Single cell sequencing has a potential for disentangling causes of azoospermia
Azoospermia - or the absence of spermatozoa - is one of the causes of infertility, a problem faced by ~15% of couples. Azoospermic testis shows different characteristics and probably causes over different groups of patients. New single cell sequencing technologies allow the study of a tissue cell by cell, but analysis of such complex and big data is still a developing and debated area. In this new study, researchers illustrate the potential and challenges in analyzing tissues at a single cell resolution, discussing future clinical applications and disentanglement of the causes and characteristics of azoospermia.
Read the article at https://link.springer.com/article/10.1007/s00439-020-02116-8
The article includes an interactive dataset of human testis at https://cells.ucsc.edu/?ds=testis