Better estimation of SNP heritability from summary statistics
Nature Genetics, Dec 2018: Doug Speed from BiRC, together with David Balding, University of Melbourne, have created SumHer, a new software for analyzing results from genetic association studies.
Doug Speed from BiRC, together with David Balding, University of Melbourne, have created SumHer, a new software for analyzing results from genetic association studies.
The two main aims of SumHer are to estimate confounding bias (measure how well an association study was performed) and to estimate SNP heritability (calculate how much of the variation in a trait is due to common genetic variants).
By applying SumHer to results for a wide variety of traits, Speed and Balding have shown that previous studies have tended to over-correct for confounding, causing them to find about 25% less causal variants that they would have with more appropriate quality control. They have also found that for each trait, common variants explain at least twice as much heritability as previously reported. The results from SumHer enable us to more efficiently analyze future data. SumHer is made freely available through the software package LDAK (www.ldak.org).
Find the article here: https://www.nature.com/articles/s41588-018-0279-5