Bioinformatics Research Centre

News

The gorilla genome reveals that our origin is a genetic patchwork

Picture of Gorilla female
An international team of researchers with the participation of researchers from Bioinformatics Research Centre, Aarhus University, has carried out the first complete sequencing of the gorilla’s genome. The gorilla is the last of four existing species of anthropoid apes to have its genome mapped. The result has just been published in the journal Nature.

Development of the Chimpanzee determined by the X Factor

Pict of chimpanzee

Genetic mutations that boost an individual’s adaptability have greater chances of getting through to X chromosomes – at least in chimpanzees, according to new research carried out by researchers at the Bioinformatics Research Centre, Aarhus University, the Section of Bioinformatics, University of Copenhagen, the Copenhagen Zoo and the sequencing center at the Beijing Genomics Institute (BGI), China. The results have just been published online in the esteemed journal PNAS.

Grant awarded to develop mathematical models for genomic data

Villum Fonden (The Villum Foundation) has awarded Lars Nørvang Andersen, Bioinformatics Research Centre, a grant for the project 'Mathematical Modelling of Whole-genome Alignment Data'. The grant covers a two-year stay at Stanford University with Assoc. Prof. Noah Rosenberg.

Picture of Lars N. Andersen


Grant for the study of biomembrane complexity

Carlsbergfondet (The Carlsberg Foundation) has awarded Lea Thøgersen, Bioinformatics Research Centre, a one-year grant of approx. DKK 570.000 for the project ‘Modeling the Complexity of a Biomembrane – with the HIV Membrane as Target system’.

Picture of Lea Thøgersen 





Scientists reveal new basic knowledge of cell membranes

Following an interdisciplinary collaboration, scientists at Aarhus University have presented a ground-breaking method to study cell membranes. A better understanding of the complexity of membrane function may give the scientists new ideas for developing new types of medical treatment against prostate cancer, for example. The results have been published in the leading journal Nature Communications. Read more..
Detail of a cell membrane

New world-leading Danish platform for genome research

Bioinformatics Research Centre takes part in a ground-breaking collaboration between four Danish universities and three companies now resulting in a research and technology platform with the capacity and ambition to map the genetic heritage of the Danish population. The new research centre called the Danish Platform for Large-scale Sequencing and Bioinformatics is financed by a five-year DKK 86 million grant from the Danish National Advanced Technology Foundation (Højteknologifonden).  Read more.. (Danish only)

Events

 May

Wednesday 16/05/12: Room 1110-223, C. F. Møllers Allé 8: 14:15 - 15:00: Birc Seminar: Aylwyn Scally, Welcome Trust Sanger Institute, Cambridge, UK: Evolution of the great apes in light of the gorilla genome sequence. Abstract.

 August

Thursday 16/8/12  - Friday 17/8/2011:BiRC Mols Meeting. 

Monday 06/8/12 - Friday 10/8/12, Aabogade 34: PhD Mini Course: Natural Computing - a formal framework for processes inspired by the functioning of living cells. Organized by BiRC, the Centre for Theory in Natural Sciences and the Department of Computer Science.
Lecturer: Prof. G. Rozenberg, Leiden University, The Netherlands, and University of Colorado at Boulder, USA. Details.

Recent Publications

Evolving stochastic context-free grammars for RNA secondary structure prediction. James WJ Anderson, Paula Tataru, Joe Staines, Jotun Hein and Rune Lyngso. BMC Bioinformatics, vol. 13:78, 2012. (doi:10.1186/1471-2105-13-78)
http://www.biomedcentral.com/1471-2105/13/78/abstract

Ancestral Population Genomics. J.Y. Dutheil and A. Hobolth. Methods in Molecular Biology, 856, vol. 2: pp. 293-313, 2012. DOI: 10.1007/978-1-61779-585-5_12
http://www.springerprotocols.com/Full/doi/10.1007/978-1-61779-585-5_12?encCode=TkVHOjIxXzUtNTg1LTk3NzE2LTEtODc5&tokenString=Pu/owpGYvUGVhECMRYy9GQ

Insights into hominid evolution from the gorilla genome sequence. J.Y. Dutheil, L.W. Hillier, G.E. Jordan, I. Goodhead, J. Herrero, A. Hobolth, T. Lappalainen, T. Mailund, T. Marques-Bonet, S. McCarthy, S.H. Montgomery, P.C. Schwalie, Y.A. Tang, M.C. Ward, Y. Xue, B. Yngvadottir, C. Alkan, L.N. Andersen, Q. Ayub, E.V. Ball, K. Beal, B.J. Bradley, Y. Chen, C.M. Clee et al. Nature, vol 483, pp. 169–175, 2012 (doi: 10.1038/nature10842)

Extensive X-linked adaptive evolution in central chimpanzees. Christina Hvilsom, Yu Qian, Thomas Bataillon, Yingrui Li, Thomas Mailund, Bettina Sallé, Frands Carlsen, Ruiqiang Li, Hancheng Zheng, Tao Jiang, Hui Jiang, Xin Jin, Kasper Munch, Asger Hobolth, Hans R. Siegismund, Jun Wang and Mikkel Heide Schierup. PNAS, vol. 109:6, pages 2054-2059, 2012. (doi: 10.1073/pnas.1106877109). http://www.pnas.org/content/early/2012/01/18/1106877109.short

Comparison of methods for calculating conditional expectations of sufficient statistics for continuous time Markov chains. Paula Tataru and Asger Hobolth. BMC Bioinformatics, vol. 12:465, 2011. (doi: 10.1186/1471-2105-12-465). 
http://www.biomedcentral.com/1471-2105/12/465/abstract

Environment-sensitive Epigenetics and the Heritability of Complex Diseases. Robert Furrow, Freddy B. Christiansen and Marcus Feldman. Genetics, vol. 189:4, pages 1377-1387, 2012.
http://www.genetics.org/content/early/2011/10/03/genetics.111.131912.short?rss=1

Exact analysis of intrinsic qualitative features of phosphorelays using mathematical models. Michael Knudsen, Elisenda Feliu and Carsten Wiuf. Journal of Theoretical Biology, pages 7-18, 2012. (doi: 10.1016/j.jtbi.2012.01.007).
http://dx.doi.org/10.1016/j.jtbi.2012.01.007

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Revised 2012.05.08