Publications

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Lassen, J. K., Wang, T., Nielsen, K. L., Hasselstrøm, J. B., Johannsen, M. & Villesen, P. (2023). Large-Scale metabolomics: Predicting biological age using 10,133 routine untargeted LC–MS measurements. Aging Cell, 22(5), Article e13813. https://doi.org/10.1111/acel.13813

Albiñana, C., Zhu, Z., Schork, A. J., Ingason, A., Aschard, H., Brikell, I., Bulik, C. M., Petersen, L. V., Agerbo, E., Grove, J., Nordentoft, M., Hougaard, D. M., Werge, T., Børglum, A. D., Mortensen, P. B., McGrath, J. J., Neale, B. M., Privé, F. & Vilhjálmsson, B. J. (2023). Multi-PGS enhances polygenic prediction by combining 937 polygenic scores. Nature Communications, 14(1), Article 4702. https://doi.org/10.1038/s41467-023-40330-w

Lindgren, L. H., Thomsen, T., de Thurah, A., Aadahl, M., Hetland, M. L., Kristensen, S. D. & Esbensen, B. A. (2023). Newly diagnosed with inflammatory arthritis (NISMA)–development of a complex self-management intervention. BMC Health Services Research, 23(1), Article 123. https://doi.org/10.1186/s12913-022-09007-w

Jeppesen, L. D., Lildballe, D. L., Hatt, L., Hedegaard, J., Singh, R., Toft, C. L. F., Schelde, P., Pedersen, A. S., Knudsen, M. & Vogel, I. (2023). Noninvasive Prenatal Screening for Cystic Fibrosis Using Circulating Trophoblasts: Detection of the 50 Most Common Disease-Causing Variants. Obstetrical and Gynecological Survey, 78(7), 393-395. https://doi.org/10.1097/01.ogx.0000947140.57660.b6

Noor, B. (2023). Optimization and Application of Convolution Neural Networks to Genomics. [PhD thesis, Aarhus University]. Aarhus Universitet.

Sørensen, S. G., Shrikhande, A., Poulsgaard, G. A., Christensen, M. H., Bertl, J., Laursen, B. E., Hoffmann, E. R. & Pedersen, J. S. (2023). Pan-cancer association of DNA repair deficiencies with whole-genome mutational patterns. eLife, 12, Article e81224. https://doi.org/10.7554/elife.81224

Rivas-González, I., Rousselle, M., Li, F., Zhou, L., Dutheil, J. Y., Munch, K., Shao, Y., Wu, D., Schierup, M. H. & Zhang, G. (2023). Pervasive incomplete lineage sorting illuminates speciation and selection in primates. Science, 380(6648), eabn4409. Article eabn4409. https://doi.org/10.1126/science.abn4409

Rivas-González, I., Andersen, L. N. & Hobolth, A. (2023). PhaseTypeR: an R package for phase-type distributions in population genetics. The Journal of Open Source Software, 8(82). https://doi.org/10.21105/joss.05054

Rolland, T., Cliquet, F., Anney, R. J. L., Moreau, C., Traut, N., Mathieu, A., Huguet, G., Duan, J., Warrier, V., Portalier, S., Dry, L., Leblond, C. S., Douard, E., Amsellem, F., Malesys, S., Maruani, A., Toro, R., Børglum, A. D., Grove, J. ... Bourgeron, T. (2023). Phenotypic effects of genetic variants associated with autism. Nature Medicine, 29(7), 1671-1680. https://doi.org/10.1038/s41591-023-02408-2

Shao, Y., Zhou, L., Li, F., Zhao, L., Zhang, B. L., Shao, F., Chen, J. W., Chen, C. Y., Bi, X., Zhuang, X. L., Zhu, H. L., Hu, J., Sun, Z., Li, X., Wang, D., Rivas-González, I., Wang, S., Wang, Y. M., Chen, W. ... Wu, D. D. (2023). Phylogenomic analyses provide insights into primate evolution. Science (New York, N.Y.), 380(6648), 913-924. https://doi.org/10.1126/science.abn6919

Musliner, K. L., Andersen, K. K., Agerbo, E., Albiñana, C., Vilhjalmsson, B. J., Rajagopal, V. M., Bybjerg-Grauholm, J., Bækved-Hansen, M., Pedersen, C. B., Pedersen, M. G., Munk-Olsen, T., Benros, M. E., Als, T. D., Grove, J., Werge, T., Børglum, A. D., Hougaard, D. M., Mors, O., Nordentoft, M. ... Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (2023). Polygenic liability, stressful life events and risk for secondary-treated depression in early life: a nationwide register-based case-cohort study. Psychological Medicine, 53(1), 217-226. https://doi.org/10.1017/S0033291721001410

Wang, X., Walker, A., Revez, J. A., Ni, G., Adams, M. J., McIntosh, A. M. & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (2023). Polygenic risk prediction: why and when out-of-sample prediction R² can exceed SNP-based heritability. American Journal of Human Genetics, 110(7), 1207-1215. https://doi.org/10.1016/j.ajhg.2023.06.006

Hayeck, T. J., Busby, G. B., Chun, S., Lewis, A. C. F., Roberts, M. C. & Vilhjálmsson, B. J. (2023). Polygenic Risk Scores: Genomes to Risk Prediction. Clinical Chemistry, 69(6), 551–557. https://doi.org/10.1093/clinchem/hvad049

Ding, Y., Hou, K., Xu, Z., Pimplaskar, A., Petter, E., Boulier, K., Privé, F., Vilhjálmsson, B. J., Olde Loohuis, L. M. & Pasaniuc, B. (2023). Polygenic scoring accuracy varies across the genetic ancestry continuum. Nature, 618, 774-781. https://doi.org/10.1038/s41586-023-06079-4

Chalmer, M. A., Kogelman, L. J. A., Ullum, H., Sørensen, E., Didriksen, M., Mikkelsen, S., Dinh, K. M., Brodersen, T., Nielsen, K. R., Bruun, M. T., Banasik, K., Brunak, S., Erikstrup, C., Pedersen, O. B., Ostrowski, S. R., Olesen, J. & Hansen, T. F. (2023). Population-Based Characterization of Menstrual Migraine and Proposed Diagnostic Criteria. JAMA network open, 6(5), e2313235. Article e2313235. https://doi.org/10.1001/jamanetworkopen.2023.13235

Winters, J. F. M., Foldager, L. & Pedersen, L. J. (2023). Postweaning growth and feeding behaviour in pigs: effect of heavier hybrid and weaning intact litters in farrowing pens for loose-housed sows. Animal, 17(1), Article 100688. https://doi.org/10.1016/j.animal.2022.100688

Cheng, Z., McLaughlin, D. L., Little, M. W., Ferris, C., Salavati, M., Ingvartsen, K. L., Crowe, M. A., Wathes, D. C. & GplusE Consortium (2023). Proportion of Concentrate in the Diet of Early Lactation Dairy Cows Has Contrasting Effects on Circulating Leukocyte Global Transcriptomic Profiles, Health and Fertility According to Parity. International Journal of Molecular Sciences , 24(1), Article 39. https://doi.org/10.3390/ijms24010039

Kringelbach, T., Højgaard, M., Rohrberg, K., Spanggaard, I., Laursen, B. E., Ladekarl, M., Haslund, C. A., Harsløf, L., Belcaid, L., Gehl, J., Søndergaard, L., Eefsen, R. L., Hansen, K. H., Kodahl, A. R., Jensen, L. H., Holt, M. I., Oellegaard, T. H., Yde, C. W., Ahlborn, L. B. & Lassen, U. (2023). ProTarget: a Danish Nationwide Clinical Trial on Targeted Cancer Treatment based on genomic profiling – a national, phase 2, prospective, multi-drug, non-randomized, open-label basket trial. BMC Cancer, 23(1), Article 182. https://doi.org/10.1186/s12885-023-10632-9

Coutant, M. P., Malmkvist, J., Foldager, L. & Herskin, M. S. (2023). Relationship among indicators of pain and stress in response to piglet surgical castration: an exploratory analysis. Journal of Veterinary Behavior, 67, 20-32. https://doi.org/10.1016/j.jveb.2023.07.001

Chatwin, H., Holde, K., Yilmaz, Z., Larsen, J. T., Albiñana, C., Vilhjálmsson, B. J., Mortensen, P. B., Thornton, L. M., Bulik, C. M. & Petersen, L. V. (2023). Risk factors for anorexia nervosa: A population-based investigation of sex differences in polygenic risk and early life exposures. International Journal of Eating Disorders, 56(9), 1703-1716. https://doi.org/10.1002/eat.23997

Poulsgaard, G. A., Sørensen, S. G., Juul, R. I., Nielsen, M. M. & Pedersen, J. S. (2023). Sequence dependencies and mutation rates of localized mutational processes in cancer. Genome Medicine, 15(1), Article 63. https://doi.org/10.1186/s13073-023-01217-z

Frank, M., Fechete, L. I., Tedeschi, F., Nadzieja, M., Nørgaard, M. M. M., Montiel, J., Andersen, K. R., Schierup, M. H., Reid, D. & Andersen, S. U. (2023). Single-cell analysis identifies genes facilitating rhizobium infection in Lotus japonicus. Nature Communications, 14(1), Article 7171. https://doi.org/10.1038/s41467-023-42911-1

Sokač, M., Kjær, A., Dyrskjøt, L., Haibe-Kains, B., Jwl Aerts, H. & Birkbak, N. J. (2023). Spatial transformation of multi-omics data unlocks novel insights into cancer biology. eLife, 12, Article RP87133. https://doi.org/10.7554/eLife.87133

Kjeldbjerg Lassen, J., Bradshaw, R., Villesen, P. & Francese, S. (2023). Statistical Modelling Investigation of MALDI-MSI-Based Approaches for Document Examination. Molecules, 28(13), Article 5207. https://doi.org/10.3390/molecules28135207

Winters, J. F. M., Kobek-Kjeldager, C., Foldager, L., Tecles, F. & Pedersen, L. J. (2023). Stress responses in pigs postweaning: Effect of heavier hybrid and weaning intact litters. Applied Animal Behaviour Science, 269, Article 106106. https://doi.org/10.1016/j.applanim.2023.106106

Borbye-Lorenzen, N., Zhu, Z., Agerbo, E., Albiñana, C., Benros, M. E., Bian, B., Børglum, A. D., Bulik, C. M., Debost, J.-C. P. G., Grove, J., Hougaard, D. M., McRae, A. F., Mors, O., Mortensen, P. B., Musliner, K. L., Nordentoft, M., Petersen, L. V., Privé, F., Sidorenko, J. ... McGrath, J. J. (2023). The correlates of neonatal complement component 3 and 4 protein concentrations with a focus on psychiatric and autoimmune disorders. Cell Genomics, 3(12), 100457. Article 100457. https://doi.org/10.1016/j.xgen.2023.100457

Frankell, A. M., Dietzen, M., Al Bakir, M., Lim, E. L., Karasaki, T., Ward, S., Veeriah, S., Colliver, E., Huebner, A., Bunkum, A., Hill, M. S., Grigoriadis, K., Moore, D. A., Black, J. R. M., Liu, W. K., Thol, K., Pich, O., Watkins, T. B. K., Naceur-Lombardelli, C. ... TRACERx Consortium (2023). The evolution of lung cancer and impact of subclonal selection in TRACERx. Nature, 616(7957), 525-533. https://doi.org/10.1038/s41586-023-05783-5

Coutant, M. P., Malmkvist, J., Foldager, L. & Herskin, M. S. (2023). The importance of carefully selecting vocalization parameters to quantify pain and stress in piglets. In Book of Abstracts - ISAE 2023: 56th Congress of the International Society for Applied Ethology ISAE 2023 (pp. 68-68).

Vodolazs'ka, D., Feyera, T., Foldager, L. & Lauridsen, C. (2023). The influence of supplementary feeding during suckling and later weaning on growth performance, incidences of post-weaning diarrhoea and immunity of piglets. Livestock Science, 276, Article 105321. https://doi.org/10.1016/j.livsci.2023.105321

Gao, H., Hamp, T., Ede, J., Schraiber, J. G., McRae, J., Singer-Berk, M., Yang, Y., Dietrich, A. S. D., Fiziev, P. P., Kuderna, L. F. K., Sundaram, L., Wu, Y., Adhikari, A., Field, Y., Chen, C., Batzoglou, S., Aguet, F., Lemire, G., Reimers, R. ... Farh, K. K. H. (2023). The landscape of tolerated genetic variation in humans and primates. Science (New York, N.Y.), 380(6648), Article abn8197. https://doi.org/10.1126/science.abn8197

Murat, F., Mbengue, N., Winge, S. B., Trefzer, T., Leushkin, E., Sepp, M., Cardoso-Moreira, M., Schmidt, J., Schneider, C., Mößinger, K., Brüning, T., Lamanna, F., Riera Belles, M., Conrad, C., Kondova, I., Bontrop, R., Behr, R., Khaitovich, P., Pääbo, S. ... Kaessmann, H. (2023). The molecular evolution of spermatogenesis across mammals. Nature, 613(7943), 308-316. https://doi.org/10.1038/s41586-022-05547-7

Christensen, D. S. & Birkbak, N. J. (2023). Therapy drives genomic evolution in metastatic cancer. OncoTarget, 14(1), 216-218. https://doi.org/10.18632/oncotarget.28379

Ahrenfeldt, J., Christensen, D. S., Østergaard, A. B., Kisistók, J., Sokač, M. & Birkbak, N. J. (2023). The ratio of adaptive to innate immune cells differs between genders and associates with improved prognosis and response to immunotherapy. PLoS One, 18(2 ), Article e0281375. https://doi.org/10.1371/journal.pone.0281375

Abbosh, C., Frankell, A. M., Harrison, T., Kisistok, J., Garnett, A., Johnson, L., Veeriah, S., Moreau, M., Chesh, A., Chaunzwa, T. L., Weiss, J., Schroeder, M. R., Ward, S., Grigoriadis, K., Shahpurwalla, A., Litchfield, K., Puttick, C., Biswas, D., Karasaki, T. ... TRACERx Consortium (2023). Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA. Nature, 616(7957), 553-562. https://doi.org/10.1038/s41586-023-05776-4

Chen, Y., Atashi, H., Mota, R. R., Grelet, C., Vanderick, S., Hu, H., GplusE Consortium & Gengler, N. (2023). Validating genomic prediction for nitrogen efficiency index and its composition traits of Holstein cows in early lactation. Journal of Animal Breeding and Genetics (Online), 140(6), 695-706. https://doi.org/10.1111/jbg.12819

Lauterbur, M. E., Munch, K. & Enard, D. (2023). Versatile Detection of Diverse Selective Sweeps with Flex-Sweep. Molecular Biology and Evolution, 40(6), Article msad139. https://doi.org/10.1093/molbev/msad139

Bergman, J., Pedersen, R., Lundgren, E. J., Lemoine, R. T., Monsarrat, S., Pearce, E. A., Schierup, M. H. & Svenning, J. C. (2023). Worldwide Late Pleistocene and Early Holocene population declines in extant megafauna are associated with Homo sapiens expansion rather than climate change. Nature Communications, 14(1), Article 7679. https://doi.org/10.1038/s41467-023-43426-5

Pedersen, E. M., Agerbo, E., Plana-Ripoll, O., Grove, J., Dreier, J. W., Musliner, K. L., Bækvad-Hansen, M., Athanasiadis, G., Schork, A., Bybjerg-Grauholm, J., Hougaard, D. M., Werge, T., Nordentoft, M., Mors, O., Dalsgaard, S., Christensen, J., Børglum, A. D., Mortensen, P. B., McGrath, J. J. ... Vilhjálmsson, B. J. (2022). Accounting for age of onset and family history improves power in genome-wide association studies. American Journal of Human Genetics, 109(3), 417-432. https://doi.org/10.1016/j.ajhg.2022.01.009

Bethune, J., Kleppe, A. & Besenbacher, S. (2022). A method to build extended sequence context models of point mutations and indels. Nature Communications, 13(1), Article 7884. https://doi.org/10.1038/s41467-022-35596-5

Antaki, D., Guevara, J., Maihofer, A. X., Klein, M., Gujral, M., Grove, J., Carey, C. E., Hong, O., Arranz, M. J., Hervas, A., Corsello, C., Vaux, K. K., Muotri, A. R., Iakoucheva, L. M., Courchesne, E., Pierce, K., Gleeson, J. G., Robinson, E. B., Nievergelt, C. M. & Sebat, J. (2022). A phenotypic spectrum of autism is attributable to the combined effects of rare variants, polygenic risk and sex. Nature Genetics, 54(9), 1284-1292. https://doi.org/10.1038/s41588-022-01064-5

Wang, T., Nielsen, K. L., Frisch, K., Lassen, J. K., Nielsen, C. B., Andersen, C. U., Villesen, P., Andreasen, M. F., Hasselstrøm, J. B. & Johannsen, M. (2022). A Retrospective Metabolomics Analysis of Gamma-Hydroxybutyrate in Humans: New Potential Markers and Changes in Metabolism Related to GHB Consumption. Frontiers in Pharmacology, 13, Article 816376. https://doi.org/10.3389/fphar.2022.816376

Yengo, L., Vedantam, S., Marouli, E., Sidorenko, J., Bartell, E., Sakaue, S., Graff, M., Eliasen, A. U., Jiang, Y., Raghavan, S., Miao, J., Arias, J. D., Graham, S. E., Mukamel, R. E., Spracklen, C. N., Yin, X., Chen, S.-H., Ferreira, T., Highland, H. H. ... Understanding Society Scientific Group (2022). A saturated map of common genetic variants associated with human height. Nature, 610(7933), 704–712. https://doi.org/10.1038/s41586-022-05275-y

Thomsen, A. H., Leth, P. M., Hougen, H. P. & Villesen, P. (2022). Asphyxia homicides in Denmark 1992-2016. International Journal of Legal Medicine, 136(6), 1773-1780. https://doi.org/10.1007/s00414-022-02787-0

Wurtz, K. E., Tahamtani, F. M., Foldager, L., Thodberg, K. & Riber, A. B. (2022). Association of range use, individual behavior, and welfare indicators of two laying hen hybrids housed under organic conditions. In M. Kjosevski, S. Waiblinger & V. Ilieski (Eds.), Proceedings of the 55th Congress of the ISAE: Animal Behaviour and Beyond (pp. 56-56). https://www.applied-ethology.org/res/ISAE_2022_PROCEEDINGS_e-version.pdf

Thomsen, A. H., Leth, P. M., Hougen, H. P. & Villesen, P. (2022). Blunt force homicides in Denmark 1992-2016. Journal of Forensic Sciences, 67(6), 2343-2350. https://doi.org/10.1111/1556-4029.15118

Franceschini, S., Grelet, C., Leblois, J., Gengler, N., Soyeurt, H. & GplusE Consortium (2022). Can unsupervised learning methods applied to milk recording big data provide new insights into dairy cow health? Journal of Dairy Science, 105(8), 6760-6772. https://doi.org/10.3168/jds.2022-21975

Sokac, M., Ahrenfeldt, J., Litchfield, K., Watkins, T. B. K., Knudsen, M., Dyrskjøt, L., Jakobsen, M. R. & Birkbak, N. J. (2022). Classifying cGAS-STING Activity Links Chromosomal Instability with Immunotherapy Response in Metastatic Bladder Cancer. Cancer Research Communications, 2(8), 762-771. https://doi.org/10.1158/2767-9764.CRC-22-0047, https://doi.org/10.1158/2767-9764.CRC-22-0047

Thomsen, T. H., Jørgensen, L. B., Kjær, T. W., Haahr, A., Vogel, A., Larsen, I. U. & Winge, K. (2022). Clinical Markers of 6 Pre-dominant Coping Behaviors in Living With Parkinson Disease: A Convergent Mixed Methods Study. Inquiry, 59. https://doi.org/10.1177/00469580221129929

Wurtz, K. E., Thodberg, K., Berenjian, A., Foldager, L., Tahamtani, F. M. & Riber, A. B. (2022). Commercial layer hybrids kept under organic conditions: a comparison of range use, welfare, and egg production in two layer strains. Poultry Science, 101(9), Article 102005. https://doi.org/10.1016/j.psj.2022.102005

Gündel, S., Munksgaard, L., Looft, C. & Foldager, L. (2022). Comparison of the feeding behaviour of primiparous and multiparous Jersey and Holstein cows kept under equal conditions throughout lactation. Journal of Dairy Research, 89(1), 37-43. https://doi.org/10.1017/S0022029922000061

Displaying results 151 to 200 out of 1378

Revised 13.01.2026

Palle Villesen